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Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome

Guangbiao Zhou, Xinchun Zhao

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 236-238 doi: 10.1007/s11684-017-0611-y

Abstract: ., tobacco carcinogens 4-aminobiphenyl and 1,3-butadiene, air toxic vinyl chloride and its reactive metabolitesSince tobacco smoke is a worldwide public health threat and vinyl chloride distributes globally and is

Keywords： genomic signature     carcinogen     aristolochic acid     tobacco smoke     vinyl chloride     hepatocellular carcinoma    

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Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 318-326 doi: 10.1007/s11684-019-0708-6

Abstract: In order to unveil ubiquitin pathway genes (UPGs) that are essential for non-small cell lung cancer (NSCLC) cell proliferation, we recently conducted a siRNA screening experiment to knockdown the expression of 696 UPGs found in the human genome in A549 and H1975 NSCLC cells. We found that silencing of one of the candidates, that encodes an E3 ubiquitin ligase essential for the repair of DNA interstrand cross-links in response to DNA damage, led to dramatic inhibition of NSCLC cell proliferation with significant -scores. Knockdown of suppressed colony forming activity of NSCLC cells. We further evaluated the significance of in NSCLCs and found that this gene was more elevated in tumor samples than in paired normal lung tissues and was inversely associated with the clinical outcome of patients with NSCLC. Moreover, expression was significantly higher in smokers than in non-smokers. These results show for the first time that is required for NSCLC cell proliferation and may have an important role in lung carcinogenesis.

Keywords： RFWD3     NSCLC     prognosis     tobacco smoke    

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Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

Guizhen Wang, Qun Zhao, Hui Zhang, Fan Liang, Chen Zhang, Jun Wang, Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 252-263 doi: 10.1007/s11684-021-0837-6

Abstract: Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase mRNAACE2 in lung tissues of non-smokers is higher than in smokers, consistent with the findings that tobaccoTobacco carcinogens inhibit SARS-CoV-2 spike protein pseudovirions infection of the cells.Given that tobacco smoke accounts for 8 million deaths including 2.1 million cancer deaths annually andSkp2 is an oncoprotein, tobacco use should not be recommended and cessation plan should be prepared

Keywords： SARS-CoV-2     tobacco smoke     benzo(a)pyrene     ACE2     Skp2    

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Study on Fire Smoke Properties of Subway Station Passageway by Simulation Experiments

Zhu Wei,Lu Ping,Liao Guangxuan,Li Peide,Hong Yixiu

Strategic Study of CAE 2005, Volume 7, Issue 2,   Pages 91-96

Abstract: Temperature relative value is provided to analyze the law of smoke temperature along the station passagewayBased on images collected, the conditions needful for coming into being smoke layer and the applicabilityof zone model are discussed in the investigation of smoke properties in subway fire.Otherwise, it is also indicated from the results of smoke component measurements that CO concentration

Keywords： subway fire     scale model     smoke temperature     smoke configuration     CO concentration    

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Study on Particle Size and Its Distribution Function of Standard Fire Smoke

Shu Xueming,Zheng Kui,Yuan Hongyong,Yao Bin

Strategic Study of CAE 2005, Volume 7, Issue 8,   Pages 51-55

Abstract:

Smoke is the important parameter of fire detection, and smoke particle size and its distribution mayaffect the sensitivity of smoke detectors directly.Particle Sizer (SMPS) were described and the particle size and its distribution of four standard fire smokeThe particle size distribution function of smoke were studied by mathematic fitting methods, and theThe results may be benefit for the foundational research on fire smoke detection.

Keywords： smoke     particle     size     distribution function    

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National Fire Protection Association, Quincy, MA, 1995Study on smoke filling combined with sprinklercooling and natural smoke exhaust

Li Sicheng,Chen Ying,Hu Longhua,Huo Ran and Yang Dong

Strategic Study of CAE 2010, Volume 12, Issue 9,   Pages 90-95

Abstract:

A mathematical model was developed for predicting smoke filling combinedwith sprinkler cooling and natural smoke exhaust.Experiments were carried out to validate the model, with experimental results, smoke filling characteristicsResults showed that smoke filling velocity combined with sprinkler cooling and natural smoke exhausthas a very small difference; the final height of smoke reduces with sprinkler cooling; for the range

Keywords： fire protection engineering     sprinkler spray     sprinkler cooling     natural smoke exhaust     smoke filling    

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Experimental study on the control of black smoke pollution from the ceramic kilns based on the mechanism

CUI Xiao, LI Caiting, WANG Fei, LI Shanhong, XIAO Chenchang, PENG Yu, ZHAI Yunbo

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 1,   Pages 109-115 doi: 10.1007/s11783-008-0021-0

Abstract: Aiming at the characteristics of carbon black, a new method of controlling the black smoke from the industrial
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Study of Fire Smoke Flow Characteristics of Horizontal Tunnel Using Longitudinal Ventilation

Lu Ping,Cong Beihua,Liao Guangxuan,Fan Weicheng,Li Peide

Strategic Study of CAE 2004, Volume 6, Issue 10,   Pages 59-64

Abstract:

The management of subway tunnel fire smoke is an important component in city public safety.In this paper, on the basis of theoretical analysis of the main factors affecting fire smoke flow inestablished to express the relationships between the critical environments, critical velocities, air speeds, smokeThe results can provide instructions for tunnel smoke managements and emergency handling.

Keywords： subway tunnel     fire smoke     buoyant effect     thermal resistance effect     critical velocity    

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The Influence of Flow Velocity on Response Sensitivity of Smoke Detectors

Xie Qiyuan,Su Guofeng,Yuan Hongyong,Zhang Yongming

Strategic Study of CAE 2005, Volume 7, Issue 11,   Pages 76-80

Abstract:

The objective of the work was to evaluate the performance of photoelectric and ionic smoke detectorsThe experiment results indicate that the sensitivity of the two kinds of smoke detectors decreases sharplyHowever, for the smoldering cottons at the entrance of FE/DE, the sensitivity of the ionic smoke detectorAccordingly, the ionization smoke detector is more suitable for those locations with high flow velocity

Keywords： flow velocity     smoke detectors     smoke particle     size distribution of particles    

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Solution of Integral Equations and Experimental Analysis of Fire Smoke Plumes in Stably Linearly Thermally

Fang Jun,Shu Xueming,Yuan Hongyong,Zheng Xin

Strategic Study of CAE 2004, Volume 6, Issue 1,   Pages 37-43

Abstract: Measurements on the different fire smoke plumes in the medium-scale and big-scale experimental roomsavailable literatures, thus this work validates the integral model and provides a good foundation for the smoke

Keywords： stably linearly thermally stratified environment     fire smoke plume     solution of integral equations     experimental    

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INTERFERENCE BY NON-HOST PLANT ROOTS AND ROOT EXUDATES IN THE INFECTION PROCESSES OF PHYTOPHTHORA NICOTIANAE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 3,   Pages 447-459 doi: 10.15302/J-FASE-2021399

Abstract: Phytophthora nicotianae were investigated because of the known allelopathy between fennel and tobacco

Keywords： fennel and tobacco rotation     infection behavior     Phytophthora nicotianae     reactive oxygen species    

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Progress in study of Hazard Analysis of Fire Smoke

Huang Rui,Yang Lizhong,Fang Weifeng,Fan Weicheng

Strategic Study of CAE 2002, Volume 4, Issue 7,   Pages 80-85

Abstract:

In building fires, smoke is one of the primary factors which result in death.This paper summarizes the researches on experiment and theory about the smoke toxicity, and introducesthe method for evaluation of smoke toxicity.Some suggestions on smoke toxicity research are also presented in this paper.

Keywords： building fires     smoke     toxicity     risk analysis    

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Study on variational principles of smoke particle shape and dimension with water mist appling

Fang Yudong

Strategic Study of CAE 2014, Volume 16, Issue 2,   Pages 93-100

Abstract: The experimental results show that water mist washes out smoke mainly by dynamics effect，cloud physicsThis paper provides scientific references for water mist technology using in smoke scrubbing of computer

Keywords： water mist     smoke particle     surface density     average diameter    

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Simulation of Effect of Forced Ventilated and Smoke Controlled System in Subway Fire Disaster

Cai Bo,Li Huiliang,Liao Guangxuan

Strategic Study of CAE 2005, Volume 7, Issue 8,   Pages 80-83

Abstract: Based on FDS, the distribution of temperature and smoke with or without forced ventilated and smoke controlled

Keywords： subway fire disaster     FDS simulation     forced ventilated smoke controlled system    

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Study of Scattering Characteristic of Fire Smoke Based on Mie Theory

Shu Xueming,Fang Jun,Shao Quan,Yuan Hongyong

Strategic Study of CAE 2005, Volume 7, Issue 1,   Pages 45-49

Abstract:

The scattering characteristic of fire smoke is a major aspect in fire smoke detection foundamentalset of experiment was designed to measure the light intensity in three directions of different fire smokeratio of scattering intensity is an important parameter for certain material, and different kinds of smoke

Keywords： fire smoke     Mie scattering     algorithm     relative ratio of scattering intensity    

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Title Author Date Type Operation

Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome

Guangbiao Zhou, Xinchun Zhao

Journal Article

Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Journal Article

Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

Guizhen Wang, Qun Zhao, Hui Zhang, Fan Liang, Chen Zhang, Jun Wang, Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou

Journal Article

Study on Fire Smoke Properties of Subway Station Passageway by Simulation Experiments

Zhu Wei,Lu Ping,Liao Guangxuan,Li Peide,Hong Yixiu

Journal Article

Study on Particle Size and Its Distribution Function of Standard Fire Smoke

Shu Xueming,Zheng Kui,Yuan Hongyong,Yao Bin

Journal Article

National Fire Protection Association, Quincy, MA, 1995Study on smoke filling combined with sprinklercooling and natural smoke exhaust

Li Sicheng,Chen Ying,Hu Longhua,Huo Ran and Yang Dong

Journal Article

Experimental study on the control of black smoke pollution from the ceramic kilns based on the mechanism

CUI Xiao, LI Caiting, WANG Fei, LI Shanhong, XIAO Chenchang, PENG Yu, ZHAI Yunbo

Journal Article

Study of Fire Smoke Flow Characteristics of Horizontal Tunnel Using Longitudinal Ventilation

Lu Ping,Cong Beihua,Liao Guangxuan,Fan Weicheng,Li Peide

Journal Article

The Influence of Flow Velocity on Response Sensitivity of Smoke Detectors

Xie Qiyuan,Su Guofeng,Yuan Hongyong,Zhang Yongming

Journal Article

Solution of Integral Equations and Experimental Analysis of Fire Smoke Plumes in Stably Linearly Thermally

Fang Jun,Shu Xueming,Yuan Hongyong,Zheng Xin

Journal Article

INTERFERENCE BY NON-HOST PLANT ROOTS AND ROOT EXUDATES IN THE INFECTION PROCESSES OF PHYTOPHTHORA NICOTIANAE

Journal Article

Progress in study of Hazard Analysis of Fire Smoke

Huang Rui,Yang Lizhong,Fang Weifeng,Fan Weicheng

Journal Article

Study on variational principles of smoke particle shape and dimension with water mist appling

Fang Yudong

Journal Article

Simulation of Effect of Forced Ventilated and Smoke Controlled System in Subway Fire Disaster

Cai Bo,Li Huiliang,Liao Guangxuan

Journal Article

Study of Scattering Characteristic of Fire Smoke Based on Mie Theory

Shu Xueming,Fang Jun,Shao Quan,Yuan Hongyong

Journal Article